The Lions are the highest ranked team in Ivy League history.
Columbia claimed the doubles point and three singles victories to upend No. 9 Oklahoma State.
The Lions face No. 9 Oklahoma State on Sunday after a win over No. 12 Baylor.
Columbia will battle Baylor tomorrow after falling to Georgia today.
The No. 13 seed Columbia battles No. 4 Georgia in the first round on Friday.
The No. 13 seeded Lions are paired with the No. 4 seeded Bulldogs in the first round of the ITA National Team Indoor Championship on Friday.
Columbia prevailed in a 4-1 defeat of Ole Miss.
Columbia hosts Ole Miss on Sunday at noon from the Dick Savitt Tennis Center in a rematch of a 4-1 Lion win during the first round of the ITA Kick-Off.
Fencing's Giana Vierheller and men's tennis' Victor Pham were named Columbia Student-Athletes of the Month for January 2018.
Columbia snagged three straight singles victories after winning the doubles point to defeat Vanderbilt.
Columbia welcomes Vanderbilt to the Dick Savitt Tennis Center on Saturday in a 1 p.m. dual on the Ivy League Network.
After defeating Ole Miss & Texas Tech, the Lions will play at the ITA National Indoor Championship.